The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine.
نویسندگان
چکیده
Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, norharman reduced also the withdrawal grooming and rearing. It is concluded that both norharman and ibogaine are inhibitors of withdrawal syndrome in morphine-dependent rats.
منابع مشابه
Effect of ibogaine on naloxone-precipitated withdrawal syndrome in chronic morphine-dependent rats.
Ibogaine, an indole alkaloid, administered intracerebroventricularly 4-16 micrograms, attenuated a naloxone-precipitated withdrawal syndrome in chronic morphine-dependent rats. It appears that ibogaine has a more consistent effect on certain selective withdrawal signs related to the locomotion. This might explain an attenuating effect of ibogaine on some withdrawal signs. However, due to comple...
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ورودعنوان ژورنال:
- Behavioural brain research
دوره 65 1 شماره
صفحات -
تاریخ انتشار 1994